[A949.Ebook] PDF Ebook 5 Acres & A Dream The Book: The Challenges of Establishing a Self-Sufficient Homestead, by Leigh Tate

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What does it take to become a successful homesteader?

Based on her popular homesteading blog, 5 Acres & A Dream, Leigh Tate shares how she and her husband Dan are facing the challenges of trying to establish a self-sufficient homestead; from defining their dream, finding property, and setting priorities, to obstacles and difficult times, to learning how to work smarter, not harder. She shares what they've learned about energy self-sufficiency, water self-sufficiency, and food self-sufficiency for themselves and their goats and chickens too. Included are copies of their homestead master plan plus revisions, homegrown vitamins and minerals for goats, and several of Leigh's favorite homestead recipes.

• Sales Rank: #58715 in Books
• Published on: 2013-11-30
• Original language: English
• Number of items: 1
• Dimensions: 9.00" h x .60" w x 6.00" l, .78 pounds
• Binding: Paperback
• 262 pages

About the Author
Leigh Tate homesteads five acres in the foothills of the southern Appalachian Mountains with her husband Dan. Their goals are simpler, sustainable, more self-reliant living, and a return to agrarian values. In addition to critter keeping, gardening, food preservation, cheese making, and woodstove cookery, Leigh loves to write about homesteading. She is the author of the popular 5 Acres & A Dream The Book: The Challenges of Establishing a Self-Sufficient Homestead, an eBook series entitled The Little Series of Homestead How-Tos, and Critter Tales : What my homestead critters have taught me about themselves, their world, and how to be a part of it. Her ongoing homestead adventures can be read at her blog, 5 Acres & A Dream The Blog.

Most helpful customer reviews

85 of 88 people found the following review helpful.
A "MUST READ"
By K. Solliday
Although I (seriously) have more than a thousand books in my non-fiction library, I rarely write reviews. I'm not sure why - I am an English teacher living on a 40 acre farm and I have actually READ all of the books I have from cover to cover (really). However, I am making an exception for this book - I couldn't put it down. It was fantastic reading from beginning to end. Now, part of the reason I might have liked it so much (disclaimer) is because, like the author, I am also middle-aged... but I truly think the reason it resonated with me was because it is an honest telling of both the good and the frustrating times the author had trying to carve out their farmstead. If you are looking for a step by step "How To" book, this isn't the one for you (although you should still buy it and read it, because it WILL help you). If you are looking for an honest look at the types of experiences one might have while trying to establish a homestead, and how one couple went about dealing with everything, this is IT!!!! I have loaned out my copy to several neighbors already, and they loved it too. We are all hoping there is more to come from this author.

55 of 57 people found the following review helpful.
5 Acres and a Dream: From Fantastic Blog to Fantastic Book
By Garrett Alley
5 Acres and a Dream is a fantastic blog, one I've been reading for a couple of years now. I've always been impressed with homesteader Leigh's (and husband Dan's) measured, logical approach. When a problem presents itself, they research and come up with the best solution for them.

When I first got a hint that maybe a book was in the works I was excited and also a bit curious. Would it just be another book about how to homestead? How much of Leigh and Dan would be in the book? Would it simply be a collection of posts from the blog?

Alas, I had nothing to worry about. The book is outstanding!

Sure, the book talks a lot about homesteading, and there are even some recipes included. The footnotes and reference section provide a wealth of further reading and information.

But where the book shines best is where the author talks about their mindset and relates their thought process -- what brought them to each decision they made.

I did not buy this book strictly as a "how to" manual for homesteading. Rather, I wanted to know more about Leigh and Dan's experience, more about the road that brought them here. But don't get me wrong, you could certainly do worse for homesteading information -- the book is stuffed full of hints, tips, and handy references for everything from cheesemaking to forestry. Often, Leigh includes alternatives or options for other ways to produce, grow, fix, or care for various components of the homestead.

And where other books can come across as preachy or condescending, 5 Acres and a Dream: the Book has a friendly, helpful tone. The author talks about why they made the decisions they made, but does not chastise those that haven't made the same choices.

She talks about what worked and what did not. She mentions their failures, rather than painting the whole experience in the rosy "DIY" light that we get on television and most other books on the subject.

I loved this book! And it's a beauty, certainly worthy of your bookshelf. Leigh packed the book with dozens and dozens of photos, really bringing their homestead to life. The writing's concise and the layout is so well done. Often, self-published books fall victim to layout/structural issues, but Leigh (as usual!) did her homework and devoted a year to getting it right. Yes, true to her philosophy, she did everything herself rather than hiring out the various parts of production. That meant learning many new opensource software programs and diving into self-publishing head first. The results speak for themselves.

I highly recommend this book.

27 of 28 people found the following review helpful.
Both Educational and Entertaining - Worth Reading!
By Benita Story
If you like Barbara Kingsolver's Animal, Vegetable, Miracle, then you are going to love Leigh Tate's book. It is not a repeat of her popular blog, 5 Acres & A Dream (which I have read since the beginning), but a very concise telling of the planning, work, research and love that she and her husband, Dan, have put into making their 5 acres as self-sustaining as possible. Not only does she explain their successes, but also their failures in order to help others who want to become self-sustaining as much as possible. The book is enjoyable to read and there are over 140 images to help explain and show you what they have done are are doing. And recipes!!! I will be telling everyone I know about this book. Thank you, Leigh, for writing this book.

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[P315.Ebook] Ebook Aircraft Propulsion and Gas Turbine Engines, by Ahmed F. El-Sayed

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The escalating use of aircraft in the 21st century demands a thorough understanding of engine propulsion concepts, including the performance of aero engines. Among other critical activities,gas turbines play an extensive role in electric power generation, and marine propulsion for naval vessels and cargo ships.

In the most exhaustive volume to date, this text examines the foundation of aircraft propulsion: aerodynamics interwoven with thermodynamics, heat transfer, and mechanical design. With a finely focused approach, the author devotes each chapter to a particular engine type, such as ramjet and pulsejet, turbojet, and turbofan. Supported by actual case studies, he illustrates engine performance under various operating conditions.

Part I discusses the history, classifications, and performance of air breathing engines. Beginning with Leonardo and continuing on to the emergence of the jet age and beyond, this section chronicles inventions up through the 20th century. It then moves into a detailed discussion of different engine types, including pulsejet, ramjet, single- and multi-spool turbojet, and turbofan in both subsonic and supersonic applications.

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• Sales Rank: #2018685 in Books
• Brand: Brand: CRC Press
• Published on: 2008-02-27
• Original language: English
• Number of items: 1
• Dimensions: 10.00" h x 7.25" w x 1.75" l, 3.75 pounds
• Binding: Hardcover
• 914 pages

Features

• Used Book in Good Condition

Most helpful customer reviews

1 of 1 people found the following review helpful.
good text but no exceptional
By J.Y. Xing
This is a good text with a lot of examples. However, the author doesn't seem to be vary famous or recognized in this field. Indeed, Mr. El-Sayed publications seem very limited. Moreover, there are several typos in the text and the author uses several Wikipedia references for the historical introduction. In my opinion, Wikipedia is unacceptable as reference for this kind of textbook even for non technical parts.

A lot of matter is covered by the author but some parts are very repetitive. Indeed, approximately half of the book deals with cycle analysis of the various aero-engine configurations.

Here is the contents of the book.

Pt. I. Aero Engines and Gas Turbines

Ch. 1. History and Classifications of Aero Engines
Ch. 2. Performance Parameters of Jet Engines
Ch. 3. Pulsejet and Ramjet Engines
Ch. 4. Turbojet Engine
Ch. 5. Turbofan Engines
Ch. 6. Turboprop, Turboshaft, and Propfan Engines
Ch. 7. High-Speed Supersonic and Hypersonic Engines
Ch. 8. Industrial Gas Turbines

Pt. II. Component Design
Ch. 9. Power Plant Installation and Intakes
Ch. 10. Combustion Systems
Ch. 11. Exhaust System
Ch. 12. Centrifugal Compressors
Ch. 13. Axial-Flow Compressors and Fans
Ch. 14. Axial Turbines
Ch. 15. Radial Inflow Turbines
Ch. 16. Module Matching.

0 of 1 people found the following review helpful.
This book is a well organized solid starting point for air breathing detail turbine engine design
By Isis
A very helpful, well organized informative detail design reference book. Great for individual component detail design as well as total engine overview design. I earned my BSAE in Air Breathing Propulsion from Embry-Riddle Aeronautical University (Daytona Beach, FL) using this book for my entire last year. This book is a solid starting point for air breathing detail turbine engine design. Its worth the price and the weight it adds to your bookshelf (or bag).

1 of 3 people found the following review helpful.
Great book
By Abdulhalim
I like this book, it gives a comprehensive general view of aircraft propulsion and gas turbine engines. Its a good place to start if you just getting into the field.

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• Sales Rank: #13938399 in Books
• Published on: 2002
• Binding: Paperback

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Key Features

• Discover the enhanced content authoring experience that comes with Drupal 8 and how to customize it
• Take advantage of the broadened multilingual and tools of the new version to provide an internationalized website
• This step-by-step guide will show you how to deploy from development, staging, and production of a website with Drupal 8's brand new configuration management system

Book Description

Began as a message board, Drupal today is open source software maintained and developed by a community of over 1,000,000 users and developers. Drupal is used by numerous local businesses to global corporations and diverse organizations all across the globe. With Drupal 8?s recent release and the exciting features it brings, this book will be your go-to guide to experimenting with all of these features through helpful recipes.

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What you will learn

• Extend Drupal through contributed or custom modules and themes
• Develop an internationalized website with Drupal's multilingual tools
• Integrate third-party front-end and back-end libraries with Drupal
• Turn Drupal into a web services provider using REST
• Create a mobile-first responsive Drupal application
• Run SimpleTest and PHPUnit to test Drupal
• Understand the plugin system that powers many of Drupal 8's new APIs to extend its functionality
• Get to grips with the mechanics of the configuration management system and the ability to import and export site configuration

About the Author

Matt Glaman is a developer at Commerce Guys. He is an open source developer who has been working with Drupal since 2013. He has also been developing web apps for many years prior to this. Since then, he has contributed to over 60 community projects, including being a co-maintainer of Drupal Commerce. While mostly focusing on Drupal and PHP development, he created https://contribkanban.com, an AngularJS application, to provide Kanban boards for the Drupal community to collaborate with.

Table of Contents

Up and Running with Drupal 8

The Content Authoring Experience

Displaying Content through Views

Extending Drupal

Frontend for the Win

Creating Forms with the Form API

Plug and Play with Plugins

Multilingual and Internationalization

Configuration Management – Deploying in Drupal 8

The Entity API

Off the Drupalicon Island

Web Services

The Drupal CLI

• Sales Rank: #93538 in eBooks
• Published on: 2016-03-08
• Released on: 2016-03-08
• Format: Kindle eBook

About the Author
Matt Glaman Matt Glaman is a developer at Commerce Guys. He is an open source developer who has been working with Drupal since 2013. He has also been developing web apps for many years prior to this. Since then, he has contributed to over 60 community projects, including being a co-maintainer of Drupal Commerce. While mostly focusing on Drupal and PHP development, he created https://contribkanban.com, an AngularJS application, to provide Kanban boards for the Drupal community to collaborate with.

Most helpful customer reviews

0 of 0 people found the following review helpful.
Must keep in your hand if you want to learn about Drupal 8
By Keywest
This is a really, really good book for a beginner to an intermediate, stretching to an advanced user. The book covers a broad topic such as how to use, programing, and the other Drupal stuffs (see the TOC). I am a Drupal developer who understands Drupal 7 and now learning a basic programming manner in Drupal 8. I feel this is something like a great Drupal 8 textbook.

Note: First I purchased the "paper" book then Amazon offer for Kindle for a few dollars. Of course I also purchased Kindle version.

0 of 0 people found the following review helpful.
Not for a beginner
By Kindle Customer
If you are comfortable writing code such as .yml files, this book may meet your needs. This book is for an experienced Drupal 8 user. If you are a newbie to Drupal 8, find an introductory book.

4 of 4 people found the following review helpful.
Get yourself productive with Drupal 8
By Todd Zebert
The Drupal 8 Development Cookbook is great for a number of different types of readers, including a:
* New D8 site builder who just “wants to get something done” that can’t be done through the GUI
* D7 developer and want to learn how to accomplish things in D8
* D8 developer who wants to round out their understanding with practical solutions
* Newbie to D8!

The strength of this book is the code “recipes” that provide complete code solutions to common (and not so common) tasks that can be quickly implemented and easily modified to meet your needs.

If you’re comfortable with object oriented PHP, Drupal 8, and the new concepts and frameworks that support it, you can easily find the recipes you need, understand how they work, and get productive quickly. If you’re not so comfortable, this book has also got you covered: Chapter 1, “UP AND RUNNING WITH DRUPAL 8” will get you started preparing your environment, installing and running D8, and understanding of common admin tasks you’ll need. Then, as you follow along the code examples you’ll come to understand how it all comes together. Don’t expect deep dives into concepts or theories or “hand holding”, rather you’ll be getting concise real-world solutions.

With Drupal 8, the Drupal community moved from a “not invented here” thinking, eschewing 3rd party technology, to a “proudly found elsewhere” attitude, choosing best of breed technologies with which to build and enhance Drupal 8. This is not only great for Drupal 8 but also easier for new Drupal developers to jump into D8 as it uses many of the same technologies they’re used to, and great for existing Drupal developers to introduce them to these technologies which will make them better developers. Glaman covers Composer, PSR-4, Twig, YAML, and of course Symfony.

Besides covering all the common coding tasks like working with pages, fields, blocks, content types, i18n, entities, etc., this book tackles the trickier aspects of Drupal 8 such as configuration management, plugins, and web services, and makes note of some of the gotchas, and explains where these are likely to be headed as D8 matures.

Finally, the two CLI tools for Drupal, Drush and Drupal Console, are covered. Besides the helpful Drupal management commands, Glaman covers scaffolding code via Console. Given the boilerplate code, directory structure, “mundane” tasks OO, PSR-4 and Symfony require, this is a feature you’re going to want to embrace. Too new to be included in the book, try the “--learning” flag on generate command to “generate a verbose code output” which means you’ll get the scaffold code with plenty of descriptive comments.

I was the technical reviewer for this book as it was being written, and Glaman showed not only a strong proficiency for coding in Drupal 8, but also the “why”, as he’s been following the continued development of Drupal 8 closely.

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Camp X was the first secret agent training camp ever to be built in North America. Established early in the Second World War by Britain’s Special Operations Executive on the Canadian shore of Lake Ontario, it trained dozens of Americans and Canadians in the arts of secret war including paramilitary skills, close combat, disguise, secret ciphers, propaganda, and undercover operations.

Many of the Camp’s graduates became secret agents in enemy-occupied Europe and Asia. Others were sent to South or Central America to counter Nazi espionage and subversion against the allied war effort. Still others worked at the Camp’s HYDRA radio station responsible for transmitting some of the most sensitive intelligence material to pass between secret services across the Atlantic.

Based on eyewitness accounts and secret files in London, Washington, and Ottawa, the cast of this real life spy adventure also includes Sir William Stephenson (‘Intrepid’), OSS chief ‘Wild Bill’ Donovan, and FBI Director J. Edgar Hoover. This edition includes a new preface by the author bringing the story up to date. A documentary based on the book will be shown on the History Channel in 2014.

“True and fascinating… told in vivid detail… With the excitement of a first-rate thriller Camp X dramatically chronicles a key period in the genesis of the international game.” - Stars and Stripes

“The course of study at Camp X reads like a James Bond training school.” - Indianapolis Star

“Required reading for any potential 007” - Sunday Mirror

• Sales Rank: #1407365 in Books
• Published on: 2014-01-26
• Original language: English
• Number of items: 1
• Dimensions: 9.00" h x .81" w x 6.00" l, 1.06 pounds
• Binding: Paperback
• 358 pages

Most helpful customer reviews

2 of 2 people found the following review helpful.
Good Book
By Machiavelli Sun Tzu
A very good compliment to the books written about "Station 17" and "Bealieu".

0 of 0 people found the following review helpful.
This book has rightly attained the status of a classic ...
By T.W. Nog
This book has rightly attained the status of a classic work in intelligence history. The special operations training at Canada's Camp X superseded in importance the too-often vacuous and over-trumpeted intelligence plotting taking place in New York and Washington, D.C. The secrecy attending that training for decades obscured its significance, and Dr Stafford is to be commended for restoring the balance.

0 of 0 people found the following review helpful.
I personally know a British gentleman who trained at Camp ...
By Joe Giles
I personally know a British gentleman who trained at Camp X at age 19. So I wanted to read this book to see if stories of his training were true. In fact they were all true.

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Across the entire body of Foo Fighters albums, the whole legendary Nirvana tale, the pre-history in the nascent Seattle scene and Grohl’s flirtations with Queens of the Stone Age and his super group side project Them Crooked Vultures, this is an utterly comprehensive, insightful chronicle of Dave Grohl’s remarkable life. Drawing on new interviews with key figures in the Grohl story, this definitive biography includes the stories of the 2007 multi-platinum opus Echoes, Silence, Patience & Grace, 2011’s Wasting Light, which saw Grohl reunited with Nirvana producer Butch Vig, and Sonic Highways, their homage to classic rock.

• Sales Rank: #144984 in Books
• Published on: 2016-04-01
• Original language: English
• Number of items: 1
• Dimensions: 8.00" h x .90" w x 5.00" l, .70 pounds
• Binding: Paperback
• 352 pages

Review
"Fascinating." —Guardian

"Foo Fighters fans and aficionados of rock music in general will relish this book." --Library Journal, 3/15/2016

About the Author
Martin James has contributed to the Independent and has also written for the Independent on Sunday, the Guardian, Mojo, Uncut, Dazed and Confused and many others. He is the author of biographies on Moby, The Prodigy, and Fatboy Slim.

Most helpful customer reviews

0 of 1 people found the following review helpful.
Five Stars
By Amazon Customer
Awesome book! Lotsa cool stories!

0 of 0 people found the following review helpful.
Nice book
By cheryl bailey
He's not running away from you, harcore Nirvana fans... he's just tryna reach out and tell you that there's another world aside from Nirvana. Thanks for this great book, Dave!

0 of 0 people found the following review helpful.
Five Stars
By john trent
It's a great book about Grohl's journey towards self-enlightenment! Thanks for the great music and lifelessons, Dave!

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Das neu bearbeitete und aktualisierte Lehr- und Übungsbuch der deutschen Grammatik eignet sich für Lerner der oberen Grundstufe und der Mittelstufe, die gründliche und zusammenhängende Kenntnisse erwerben möchten. Die übersichtlich strukturierte Standardgrammatik wurde mit einem modernen, sehr lernerfreundlichen und übersichtlichen neuen Layout und aktualisierten und modernisierten Übungs- und Beispielsätzen ausgestattet. Die ursprüngliche Struktur und Progression und der bewährte schnelle Wechsel von Erklären und Üben bleiben vollständig erhalten. Das Lernziel ist die sichere Beherrschung der Sprache in der schriftlichen und mündlichen Anwendung. Die Grammatik ist universell einsetzbar und eignet sich als kursbegleitende Übungsgrammatik sowie zum Selbststudium. Eine Übersicht über die Konjugation und Deklination hilft dem Lernenden, sich schnell zu orientieren. Zusätzlich ist ein Lösungsschlüssel (978-3-19-407255-8) erhältlich.

• Sales Rank: #955341 in Books
• Published on: 2009-07-08
• Original language: German
• Number of items: 1
• Dimensions: 9.06" h x 1.02" w x 6.73" l, .84 pounds
• Binding: Paperback
• 396 pages

Most helpful customer reviews

8 of 8 people found the following review helpful.
Just essential for students of the German language
By MARIA PERSICO
I had been recommended by a German teacher that I should get this grammar book and fortunately, I followed her advice. I can only say that it is just perfect for those, like myself, who find that learning German is very demanding. This book can defintely clarify your doubts on the difficulties of Germnan grammar, as it has plenty of exercises and clear explanations.

I believe it is an essential tool and I would certainly recommend it.
The delivery was ahead of the dealine and went just smoothly.

2 of 2 people found the following review helpful.
Best and Greatest German Learning Material: I highly recommend it!!
By Learned German for Years
I lived in a German speaking country, where I had to learn the language, from zero, no previous knowledge at all!. I lived there for over 10 years, took many classes at several schools, researched and used several books and learning material during the learning process. I am glad to have learned the language to a proficient level. After having achieved this goal, I found that the best book to keep of all of the ones I bought was this master piece. I did keep other good books and material as well, but this book from Dreyer-Schmidt is for me like my "German Bibble", there I find all the answers to all my questions, it is great in the process of learning and after that to keep the language and do not forget what you learnt.. I recommend this book highly to anyone interested on mastering the German language and to keep it !!!!

It comes in several languages, for the beginners, but I recommend trying using the German one, thus one can understand and learn the REAL words, because German is German.

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• Published on: 1705
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Waking and the Reticular Activating System in Health and Disease, by Edgar Garcia-Rill

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Waking and the Reticular Activating System in Health and Disease provides a comprehensive overview on the “activating” properties of the RAS. In health, the RAS provides the basis against which we assess the external world, and in disease it distorts that world and shatters our self-image. This book describes the physiology of each process, how it is disturbed in each disorder, and what the most appropriate treatment should be.

Dr. Garcia-Rill, along with contributions from leading specialists, discusses the understanding of the RAS as a system not only modulating waking, but also in charge of survival mechanisms such as fight vs flight responses and reflexes. The full spectrum of these functions helps explain the complexity of symptoms evident in such disorders as disparate as schizophrenia and Parkinson’s disease. The book reviews the mechanisms that control waking and arousal, and especially how those mechanisms malfunction in certain neurological and psychiatric disorders.

• First comprehensive overview on the RAS and its role in schizophrenia, major depression, autism, Parkinson’s, Alzheimer’s, and other neurologic and mental diseases
• Offers a new way of thinking about brain function and the role of the RAS in our waking lives
• Written by a leading translational neuroscience researcher with contributions by specialists in the field

• Sales Rank: #3158924 in Books
• Published on: 2015-05-11
• Original language: English
• Number of items: 1
• Dimensions: 9.10" h x .90" w x 6.20" l, .0 pounds
• Binding: Hardcover
• 330 pages

Review
"...an excellent book...I highly recommend it to clinicians involved in diagnosing and treating patients with sleep and neuropsychiatric disorders. Score: 91 - 4 Stars" --Doody's

About the Author
Dr. Edgar Garcia-Rill is a Professor of Neurobiology and Developmental Sciences, and Psychiatry in the College of Medicine at the University of Arkansas for Medical Sciences (UAMS). He also holds graduate faculty appointments in the Neurobiology and Developmental Sciences and Interdisciplinary Biomedical Sciences program. He is the Director of the Center for Translational Neuroscience, a Center of Biomedical Research Excellence.

Most helpful customer reviews

0 of 0 people found the following review helpful.
Editorial from Journal of Sleep Science by dr. S. Datta.
By Edgar Garcia-Rill
This issue of Sleep Science contains two excellent review articles by Garcia-Rill and his colleagues examining the role of reticular activating system, especially the pedunculopon- tine (PPT) nucleus, in the pathophysiology of insomnia, schizophrenia, and other neuropsychiatric disorders. The PPT nucleus is one of the major aggregations of cholinergic neurons in the mammalian brainstem capable of synthesizing acetylcholine, but also other neurotransmitters and peptides. In addition, PPT cholinergic cells also synthesize a gaseous neuromodulator, nitric oxide. Interest- ingly, cells in the PPT are involved in regulation of both wakefulness and REM sleep.
About 10 years ago, the Garcia-Rill lab reported for the first time the presence of electrical coupling through gap junc- tions of some cells in each of three major elements of the arousal system, including the PPT. This discovery helped explain how gap junction blockers like halothane and propo- fol can put us to sleep so rapidly. A year later, his lab resolved a 20-year mystery, the mechanism of action of the stimulant modafinil used in the treatment of narcolepsy. Modafinil was found to increase electrical coupling and coherence of cell activity in the same centers found to manifest electrical coupling, increasing arousal. All of these breakthroughs are addressed in review articles from Garcia-Rill lab appear- ing in this issue of Sleep Science. However, these major contributions are only the tip of the iceberg.
About 5 years ago, Garcia-Rill first reported the presence of gamma band activity in these arousal-related centers, sug- gesting that this system generates its own high frequency activity. They went on to show that this activity was mediated by intrinsic membrane oscillations due to the presence of high threshold voltage-dependent N- and P/Q- type calcium channels. This year, they found that a protein over expressed in schizophrenia and bipolar disorder blocks the manifestation of gamma band activity in the PPT. They also showed that one of the mechanisms by which lithium has a therapeutic effect is because it blocks the over expressing protein to allow the maintenance of gamma band activity, which is reduced in these disorders. So much for the 60-year mystery of the action of lithium. These findings are described in his Sleep Science review on schizophrenia and bipolar disorder, which are characterized by serious sleep- wake disturbances.
Also this year, the Garcia-Rill group reported the presence in the PPT of different populations of cells with only N-type, only P/Q-type, or both N- and P/Q-type calcium channels. These populations may correspond to in vivo studies show- ing “REM-on”, “Wake-on” and “Wake/REM-on” cells, respec- tively, resolving a 30-year mystery. This segregation suggests that waking and REM sleep are controlled by two separate intracellular pathways, which we investigated for many years. This discovery implies that the gamma band activity observed during waking is different from that seen during REM sleep. In his Sleep Science review on insomnia, Garcia-Rill proposes a novel mechanism for this disorder (excessive waking due to increased expression or activity in the CaMKII-P/Q-type channel system). This imaginative proposal provides excellent new therapeutic targets for this difficult to treat condition.
In addition, Garcia-Rill provides preliminary data for the mechanism behind the developmental decrease in REM sleep (decreased expression of N-type calcium channels mediating REM sleep across development), resolving a 50-year mystery. They also suggest a mechanism behind the basic rest-activity cycle (BRAC) (alternation of CaMKII-P/Q-type channel waking- like gamma band activity with cAMP/PK-N-type channel REM sleep-like gamma band activity). I would not bet against this theory in resolving this 75-year mystery.
A new book entitled, “Waking and the Reticular Activating System” outlines his work over 40 years on locomotion, arousal, and waking, and is peppered with innovative ideas, solutions, and suggestions. In fact, one reason Garcia-Rill became interested in the PPT was due to his studies in the 1980 s and 1990 s on the mesencephalic locomotor region. This work led to a series of discoveries related to spinal cord injury, including investigations reducing hyper-reflexia after spinal cord injury using passive exercise, and the descending pathways mediating changes in postural muscle tone and locomotion [16]. This work emphasized the fact that the PPT not only triggers cortical arousal through its ascending projections through the intralaminar thalamus, but also activates descending postural and locomotion pathways in charge of fight-or-flight responses. These efforts led to the suggestion that stimulation of the PPT could be used for the treatment of the postural and walking deficits in Parkinson- ism. It took 20 years, but the PPT is now a region implanted in Parkinson’s patients to perform deep brain stimulation, with impressive clinical outcomes.
Another area of study by this lab involves the midlatency auditory evoked P50 potential. The Garcia-Rill lab was the first to describe decreased habituation of the P50 potential in posttraumatic stress disorder, one of the few markers for the disorder that has withstood the test of time. They also were the first to show decreased habituation of the P50 potential in depression, Parkinson’s disease, and Huntington’s disease. They were the first to identify the rodent equivalent of the P50 potential, the P13 potential. These waveforms are present during waking and REM sleep (they are sleep state-dependent), are blocked by scopolamine (they are cholinergic), and habituate rapidly (reticular in physiology), indicative of their origin in the PPT. That is, the P50 potential is a marker for PPT output in the human, an unexplored but potentially productive research area.
As if this were not enough, Garcia-Rill has co-authored several law reviews. These articles address the contributions of modern neuroscience to the formulation and application of the law. His law reviews run the gamut from scientific evidence to violence and future dangerousness, to intent and culpability. In keeping with new responsibilities as a modern neuroscientist, Garcia-Rill makes sure that his read- ers in the legal profession are exposed to the latest concepts derived in our field.
The fact is that the Sleep Science reviews reveal only some of the enormous range of this lab. Few individuals have contributed so many advances to the sleep field. These are not merely incremental advances but represent paradigm shifts characterized by imagination and intelligence. We sleep researchers have been introduced to the wonderful, puzzling, and inescapable world of gamma band activity by this group. These revelations have produced some of the most astounding advances in the sleep-wake field. I for one can hardly wait for the next mystery to be solved.
Garcia-Rill has opened the door to gamma band activity in the ascending reticular activating system (ARAS), with ever increasing implications. Their proposal that this system is involved in the process of preconscious awareness has major ramifications for volition and free will, as well as conscious- ness. We are all familiar with the profound sleep distur- bances caused by dysregulation of this region, but the significance of these changes has much wider implications for neurological and psychiatric disorders. The door has been opened by this lab and we should not only salute their accomplishments, but join them in their search for the answers to the mysteries of the ARAS.

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